Initially known as a predominantly respiratory disease, there is currently no doubt that COVID-19 is increasingly emerging as a prothrombotic condition. Observational studies, as well as published and anecdotal case reports have highlighted the thrombotic manifestations of COVID-19, with particular emphasis on the strong association between D-dimer levels and poor prognosis.1,2 While the COVID-19 clotting … Read more
Randomized clinical trials (RCTs) contributed the most to our knowledge to date in management of stroke patients. Despite the strengths of RCTs, they can be very costly and sometimes not feasible. In this year AHA Scientific Sessions, Jonathan P. Piccini, MD highlighted areas where observational data have been informative to address difficult clinical questions that … Read more
In research, randomized controlled trials (RCTs) are seen as the best method for looking at interventions effect. In RCTs, the preference of patients (or their health care providers) for a treatment is not taken into account. This could lead to those patients refusing to be randomized and will never even enter the trial. Because these … Read more