Our virtual AHA20 has started with all of the science, engagement and excitement!!! Since many of us are working and still want to squeeze in some time to check out what is going on at AHA20, I have decided to summarize clinical trials to look out for at AHA20 with their brief description.
Friday 11/13/2020
| Trial Name | Arrest Trial
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| Trial title | Advanced Reperfusion Strategies For Refractory Ventricular Fibrillation Out-of-hospital Cardiac Arrest
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| Description | In this trial, patients (18-75 years old) with refractory ventricular fibrillation/pulseless ventricular tachycardia out-of hospital cardiac arrest, who are transferred by emergency medical services (EMS) with ongoing mechanical cardiopulmonary resuscitation (CPR) or who are resuscitated, were randomized to receive either early Extracorporeal Membrane Oxygenation (ECMO) or standard Advanced Cardiac Life Support (ACLS) Resuscitation [1]
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Saturday 11/14/2020:
ALPHEUS, ATLANTIS, and RIVER Trials
| Trial Name | Alpheus Trial
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| Trial title | Assessment of Loading With the P2Y12 Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting.
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| Description | This is a multicenter study in stable patients undergoing elective PCI with a randomization between clopidogrel and ticagrelor. The primary ischemic endpoint is peri-procedural MI and myocardial injury and safety endpoint is bleeding by BARC definition [2]. |
| Trial Name | Atlantis Trial
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| Trial title | Anti-Thrombotic Strategy After Trans-Aortic Valve Implantation (TAVI) for Aortic Stenosis
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| Description | This trial looks at the strategy of anticoagulation with novel anticoagulant, apixaban, compared to the current standard of care in patients who had a successful TAVI. The randomization is performed according to the presence or absence of a mandatory indication for anticoagulation, including atrial fibrillation or venous thromboembolic disease [3]. |
| Trial Name | RIVER Trial
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| Trial title | RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial
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| Description | This trial compares Rivaroxaban Versus Warfarin In Patients With Bioprosthetic Mitral Valves And Atrial Fibrillation [4].
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Sunday 11/15/2020:
One-Month DAPT
| Trial Name | One-Month DAPT
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| Description | One month dual antiplatelet Therapy Followed By Aspirin Monotherapy After Drug Eluting Stent Implantation.
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References:
- ARREST trial: https://www.clinicaltrials.gov/ct2/show/NCT03880565
- ALPHEUS trial: https://clinicaltrials.gov/ct2/show/NCT02617290
- ATLANTIS trial: https://clinicaltrials.gov/ct2/show/NCT02664649
- RIVER trial: https://clinicaltrials.gov/ct2/show/NCT02303795
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