An Antidote To Factor Xa Inhibitors – Andexanet Alfa

“Success consists of going from failure to failure without loss of enthusiasm.” Winston Churchill Treatment options for systemic anticoagulation (AC) have grown substantially during the last several years. One of the most common indications for AC is to reduce the risk of embolic stroke secondary to atrial fibrillation (AF). Although there are multiple reasons to … Read more

Options To Rat Poison – Other Mousetraps?

“The policy of being too cautious is the greatest risk of all.” Jawaharlal Nehru Of all the potential complications associated with atrial fibrillation (AF), stroke is the most feared. Attempting to predict a stroke has proven to be a daunting task. The mechanism by which AF leads to a stroke is undoubtedly due to the … Read more

Killing Cardiac Cells

I was in the mall one day and the saleswoman started talking about her health issues. For starters, I am not sure why she entrusted me with this information, but okay. So why is that conversation interesting enough to write about? Well, the lady was 20 years of age and she had undergone several cardiovascular … Read more

The Lack Of New Drugs For Rhythm Control Of Atrial Fibrillation: A Stagnant Pipeline

“It does not matter how slowly you go as long as you do not stop” – Confucius   Atrial fibrillation (AF) is the most common arrhythmia in the world1. This potentially malignant condition can dramatically raise the risk for stroke. Many patients are symptomatic, and those with congestive heart failure may suffer worse outcomes when … Read more